Perturbative solution to susceptible-infected-susceptible epidemics on networks.

Herein we provide a closed form perturbative solution to a general M-node network susceptible-infected-susceptible (SIS) model using the transport rates between nodes as a perturbation parameter. We separate the dynamics into a short-time regime and a medium-to-long-time regime. We solve the short-time dynamics of the system and provide a limit before which our explicit, analytical result of the first-order perturbation for the medium-to-long-time regime is to be employed. These stitched calculations provide an approximation to the full temporal dynamics for rather general initial conditions. To further corroborate our results, we solve the mean-field equations numerically for an infectious SIS outbreak in New Zealand (NZ, Aotearoa) recomposed into 23 subpopulations where the virus is spread to different subpopulations via (documented) air traffic data, and the country is internationally quarantined. We demonstrate that our analytical predictions compare well to the numerical solution

Early onset Charcot-Marie-Tooth neuropathy type 2A and severe developmental delay: expanding the clinical phenotype of MFN2-related neuropathy

Charcot-Marie-Tooth (CMT) syndromes are a group of clinically heterogeneous disorders of the peripheral nervous system. Mutations of mitofusin 2 (MFN2) have been recognized to be associated with CMT type 2A (CMT2A). CMT2A is primarily an axonal disorder resulting in motor and sensory neuropathy. We report a male child with psychomotor delay, dysmorphic features and weakness of lower limbs associated with electrophysiological features of severe, sensory-motor, axonal neuropathy. The patient was diagnosed with early onset CMT2A and severe psychomotor retardation associated to c.310C>T mutation (p.R104W) in MFN2 gene. CMT2A should be considered in patients with both axonal sensory-motor neuropathy and developmental delay